Solid lipid nanoparticles (SLN) are a novel and innovative therapeutic delivery system. Clear advantages include the composition (physiological compounds), the effective production process (especially the possibility of large scale production), avoidance of organic solvents during the production process and the possibility of producing highly concentrated lipid dispersions. SLN are a characterization of the formulation requires several analytical methods and complex system due to the physical state of the lipid. There are a large number of methods available to characterize nanoparticles. Some approaches, such as DLS for size, or nuclear magnetic resonance (NMR) for diffusivity, are unique to the analysis of nanoparticles compared to that of more macroscopic species. Other techniques, such as differential scanning calorimetry (DSC) or X-ray diffraction, are not significantly affected by the sub micrometer particle size. Rather, in these cases, it is the interpretation of the results in the context of the problem at hand that renders the corresponding method relevant.
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